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Methods We searched MEDLINE/PubMed database using a combination of keywords bipolar disorder + inflammation, bipolar disorder + cytokine, bipolar disorder + lymphocyte, bipolar disorder + autoimmune, lithium + lymphocyte, lithium + cytokine, lithium + inflammation (Figure 1)

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This dual action makes tramadol effective for various pain types but also means it affects multiple body systems

Exercise activates hormesis, where exposure to mild stress triggers adaptive responses in cells and organisms, enhancing their resistance to higher levels of stress and improving overall health and function

At the start of the study and at its end 16 weeks later, the participants took a series of repeated trials in which they could earn money by performing a "hard" task, which involved typing with their nondominant hand, or an "easy" one, typing with their dominant hand