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ICH Q1A(R2) Stability Testing of New Drug Substances and Drug Products Scientific Guideline
In clinical trials, tirzepatide led to 1522.5% average weight loss over 72 weeks, compared with 8% average weight loss with liraglutide 3.0 mg over 56 weeks
A dose that keeps weight perfectly stable but causes ongoing nausea, fatigue, constipation, or poor intake may not be the best long-term fit
doi:10.1101/2025.10.08.681212 Lundgren JR, et al
The standard titration schedule helps you adjust to this dual action
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