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Natural GLP-1 Agonists From the Plant World Natural GLP-1 agonists are compounds that mimic or amplify GLP-1 activity in a way similar to how prescription drugs work, just more modestly

In studies performed in rats, samples taken 20 minutes following a high-fat diet meal showed elevated GLP-1 in the lymph collected from the mesenteric lymph duct rather than the PV, while no difference was observed after a low-fat meal (66)

Importantly, a pilot study in older adults with T2DM and obesity reported that semaglutide preserved the SMM percentage of the extremities despite a decrease in total muscle mass [55]