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reported that MTX caused weight loss due to malabsorption and enterocolitis in rats (Reference Fox, Kripke and De Paula37,Reference Jahovic, Cevik and Sehirli38)
All chronic diseases, including COVID-19 with the long-COVID-19-syndrome (271), are characterized by the presence of persistent chronic inflammation and sustained generation of reactive oxygen and nitrogen species that when confronted with inadequate antioxidant defenses (likely leading components of anti-inflammaging) precipitate excessive oxidative stress
