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The Phase 2 trial published in the New England Journal of Medicine studied doses ranging from 1mg to 12mg weekly
The class 2 defect results in the synthesis of a receptor protein that is not properly processed in the endoplasmic reticulum (ER) and Golgi apparatus and therefore is not transported to the plasma membrane
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Gastroenterology 167 , 14571459 (2024)
Animal studies on BPC-157 have demonstrated a favorable safety profile, with no established LD50 (lethal dose) and no documented organ toxicity, carcinogenicity, or mutagenicity at tested doses
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