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Serious adverse effects , while less common, require immediate medical attention and include: Acute pancreatitis : Characterized by severe, persistent abdominal pain radiating to the back, often accompanied by nausea and vomiting

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Common side effects associated with retatrutide consistent with the broader GLP-1 receptor agonist class, as described in the Summary of Product Characteristics (SmPC) for licensed medicines such as Wegovy (semaglutide 2.4 mg) and Mounjaro (tirzepatide) include: Nausea (particularly during dose escalation) Vomiting Diarrhoea or constipation Decreased appetite Injection site reactions such as mild redness or discomfort Increased heart rate , which has been observed with incretin-based therapies These gastrointestinal effects are typically most pronounced when starting treatment or increasing the dose, and they often improve over time as the body adjusts

The dose is then typically increased gradually every three to four weeks based on tolerance and your prescriber's recommendations