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For Zepbound (tirzepatide), common GI side effects include nausea (24-30%), diarrhea (18-23%), vomiting (8-12%), and constipation (16-17%), with rates varying by dose

This delays gastric emptying, suppresses appetite, and leads to smaller portions and fewer cravings

Gastrointestinal side effect timing Beyond nausea, GLP-1 agonists can cause constipation, diarrhea, bloating, and acid reflux

13.7% average weight loss

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