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Part of the reason is that anti-TNF agents block one specific cytokine while leaving the rest of the inflammatory network intact

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At ~504 Da molecular weight with only two amino acid residues (Tyr-Ile core), it falls below the typical size range of bioactive peptides

If your internal appeal is denied, you still have options - requesting an independent external review within 120 days could overturn the decision, with success rates around 40%

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