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EHMT2/G9a stood out as a potential target: it is an epigenetic regulator expressed in immune cells, including macrophages, and its previously determined half maximal effective concentration (EC 50 ) (PubChem AID: 504332) matches the effect range (10100 M) seen in our study 39
McAllister MJ, Basham SA, Waldman HS, Smith JW, Mettler JA, Butawan MB, et al
Diabetes Care 2006;29(11):2365-2370
The HIF-1-ITF axis maintains the intestinal epithelial barrier and decreases inflammation
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