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Mechanism: VEGF pathway modulation promoting physiological angiogenesis and endothelial protection, anti-inflammatory effects reducing vascular damage

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Many people begin to notice subtle changes within 12 weeks, especially improvements in energy, mood, and motivation

(2017) 6:S761

In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different