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Jul-Sep 2021;9(3):e137
Igniting hope: harnessing NLRP3 inflammasome-GSDMD-mediated pyroptosis for cancer immunotherapy
The protocol is administered as subcutaneous injections over a 4-week or 8-week cycle
Starting with a lower dose and gradually increasing (dose titration) helps minimise these symptoms
The reason for retaining such high binding affinity is likely due to the hydrophobic interactions involving the C-terminus of the peptide
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