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Alanine scanning studies have identified specific amino acids, including His7, Gly10, Phe12, Thr13, Asp15, Phe28, and Ile29, that play crucial roles in receptor binding and activation

101 Whereas, the classical explanation is that, while hydroxychloroquine impaired phago/lysosomal function, it also appears to work in a lysosome-independent manner by impacting on intracellular TLRs, particularly TLR9, by inhibiting the production of TNF, and by interfering with the processing of the conversion of the membrane-bound pro-TNF into soluble mature protein

Horiguchi, T., Tachikawa, S., Handa, M., Hanazono, K., Kondo, R., Ishibashi, A., Banno, K., Effects of Suplast tosilate on airway inflammation and airway hyperresponsiveness, J.Asthma 38: 331-336 (2001)

Trial populations, doses, durations, and study designs may differ

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You're below therapeutic threshold