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Both GIP and GLP-1 are incretin hormones released in response to nutrient uptake in the gut, however GIP is responsible for ~2/3 of the total effect, allowing a synergistic effect with tirzepatides mechanism

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Predefined sensitivity analyses to determine potential confounding influence were conducted with the same statistical analysis set-up removing (1) patients with IIH without papilledema (IIH-WOP), and (2) patients with pre-existing migraine

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2 h An 8-week dose-escalation regimen was used, with dose escalation from 0.25 mg per week for 4 weeks then 0.5 mg per week for another 4 weeks, followed by maintenance dose of 1 mg per week throughout remainder of the treatment period