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If you have tried a GLP-1 and did not tolerate it, phentermine offers a genuinely different mechanism that may work for you
What the research shows The most-cited data come from the STEP 1 trial extension (Wilding et al., Diabetes, Obesity and Metabolism , 2022)
A recent study found that 30% of patients stopped within four weeks, and less than half stayed on the medication for 12 weeks or more
Always discuss your plan with your clinician, who can tailor the taper based on your current dose and how long you have been on treatment
How Tirzepatide Works Tirzepatide is not a blood pressure medicine
Expecting reasonable, gradual progress rather than immediate transformation leads to better adherence and more sustainable results
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