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However, semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that is broken down by proteolytic enzymes rather than the CYP450 system

Evidence for GLP-1RAs in HFpEF Seven RCTs have shown the cardioprotective benefits of GLP-1RAs in patients with T2D, regardless of their cardiovascular risk profiles

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Bioavailability did not differ significantly between healthy participants and those with T2D [66]

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