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SGLT2 inhibitors, such as canagliflozin and dapagliflozin, are FDA-approved to lower blood sugar in adults with type 2 diabetes

Weeks 5-8 (first dose increase) After four weeks at the starting dose, most protocols call for the first dose increase

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Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia