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With a 6-day half-life, more frequent smaller doses accumulate toward nearly the same ceiling holding the weekly total constant, the steady-state peak falls only about 19% on q3d and about 17% on q3.5d, not the 57% the swing figure might suggest

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10.1016/j.foodchem.2022.132531 75 SignorileP

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In other words a lesion with moderate atypia may contain areas of melanoma-in-situ within it