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impaired in type 2 Cagrilintide Long-acting amylin analogue (engineered copy) Binds to amylin and calcitonin receptors Half-life: ~7 days Once-weekly subcutaneous injection Designed specifically for chronic weight management How Cagrilintide works in the body Cagrilintide exerts its effects by binding to amylin receptors specifically the calcitonin receptor in combination with receptor activity-modifying proteins (RAMP1 and RAMP3)

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doi: 10.1080/08927022.2019.1609671 198 SalehiSMKonerDMeuwlyM

10.1016/j.jpba.2021.114040 14 FrudeE.McKayF