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B12 is essential for a properly functioning central nervous system we know that dysfunction can lead to depression

The mechanism of tolerance appears to be pharmacodynamic in nature

This isnt just something thats on the surface but something thats inside

Whether that is relevant to you depends on your goals

Memory loss is one symptom you dont want to neglect: The neurologic complications of B12 deficiency are often reversible, but not always, warns Green

This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]