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Health Perspect.,2001 111

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Nuclear factor erythroid 2-related factor 2 (Nrf2) is notably representative and is activated by NAPQI-induced redox status changes

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Importantly, our findings differ from work demonstrating prevalence of iNOS-expressing Mdcs at peak neuroinflammation, challenging the general concept that ARG1 is a signature enzyme associated with resolving inflammation 9,10

Allosteric terms in the model play a role largely in stabilizing the steady-state concentrations of the methionine cycle substrates, especially SAM, in the face of large fluctuations in the methionine input