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The log-ratio coverage and B-allele frequencies were GC-corrected, jointly segmented by circular binary segmentation and subjected to purity and ploidy inference with manual review of candidate solutions

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4.3.3 Integration of ammonium metabolism inhibition with immune checkpoint blockade The inhibition of glutamine utilization by DON (Gln antagonist) and its prodrugs, such as JHU 083 and DRP-104, has been shown to enhance antitumor immune responses (142, 227, 228), suggesting a potential strategy when combined with immune checkpoint inhibitors