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"Our approach emphasizes stewardship of the entire treatment continuum, from start through maintenance, with a clear clinical framework for when therapy can be safely reduced and, when appropriate, discontinued." Today, there is no clear standard for how long patients should stay on GLP-1s or how to safely come off

These distinct mechanisms mean the medications operate independently, reducing the likelihood of direct pharmacological conflict

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This finding holds significant importance, noting that phase 3 studies have typically excluded patients with a history of psychiatric disorders, resulting in a lack of reference data for understanding the long-term consequences of GLP-1 RAs use in patients with obesity

A recent review in Fertility and Sterility emphasized how GLP-1s are being considered as part of preconception care for women with PCOS and obesity