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Clinical evidence suggests a small increased risk of gallbladder-related complications during semaglutide therapy

M., Cox, S

Weight regain can begin 8 to 12 weeks after complete discontinuation (Wilding et al., NEJM 2022)

Document symptom timing, check blood glucose during episodes, and discuss whether dose adjustment, symptomatic treatment, or mental health referral is appropriate

They are a sign that your body is adapting to a new metabolic reality, and it needs some support during the transition

This includes the possibility of Medicare coverage starting in 2026, which will provide further relief for senior patients