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For a long time, glucagon was treated as the enemy of weight loss, since it raises blood sugar on its own

These medications are valuable, and throwing away something that seems perfectly usable can feel counterintuitive

The SELECT trial (published in NEJM 2023) established semaglutide's cardiovascular benefits in patients with established cardiovascular disease and overweight or obesity but without diabetes

Cardiovascular Diabetology, 20 (1), 225

M.Orbn-KisK.SzatmriS.et al (2025)

At Longevity Medical Institute, that philosophy matters because symptoms alone can point in the right direction, but they can't tell the whole story