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doi: 10.1186/s12933-023-02074-1 51 Paunel-GrglAWackerMEl AitaMHassanSSchlachtenbergerGDeppeAet al
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Histamine binds to receptors on small blood vessels, making vessel walls more permeable (which allows fluid to leak and form the raised wheal) and dilating the vessels (which creates the surrounding redness)
A ratio of fluorescence intensities measured at 340 nm and 380 nm was calculated minus the background fluorescence
In vivo studies in iron-deficient mice confirm this: erythrocytes exhibit increased PS exposure, reduced glutathione (GSH) levels, and accelerated clearance, with these defects reversed by iron repletion (Kempe et al., 2006)
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