Delayed gastric emptying can cause nausea and vomiting, sometimes leading to dehydration and electrolyte disturbances
Examples of synthetic GLP-1 are Semaglutide (ozempic, wegovy) which last 1 week, Liraglutide (Victoza, Saxenda) which last 24 hours, Tirzepatide (Mounjaro, Zepbound) which last 1 week and also targets GIP, and finally Exenatide (Byetta, Bydurette) which can last hours to a day
So all of those changes conspire to put weight on
This effect seems to be more pronounced in older men
At this time, Medicare only covers these medications for patients with diabetes, cardiovascular disease (such as stroke or heart attack), and obstructive sleep apnea
Both immunoreactive gut glucagon and L-cells are present most abundantly in the distal small intestine and colon (31, 62)