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Unlike peptides that require brain penetration, klotho enhances cognition when administered peripherallydespite not crossing the blood-brain barriersuggesting it acts through systemic signaling mechanisms that remain incompletely understood
Week 1 to 3 is just trial and error
Statements Author contributions DM: Screening and selection of studies, extraction of study data, contact with Lareb and the TIS of Switzerland, main author of the manuscript
doi: 10.1172/jci.insight.95997 30
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