As the native GLP-1 has a short half-life, GLP-1 analogues have been produced to prolong effects and many of them could cross blood-brain barriers (BBB) such as Liraglutide (LG), lixisenatide, and exendin-4
Xing C, Zhao H, Zhang J, He B (2022) Effect of metformin versus metformin plus liraglutide on gonadal and metabolic profiles in overweight patients with polycystic ovary syndrome
Glutathione conjugation as a bioactivation reaction [online]
XULTOPHY [ZUL toh fye] pairs liraglutide with insulin degludec (Tresiba)
The evidence base for GLP-1 agonists in binge eating disorder remains preliminary, with most data coming from case reports, small case series, and secondary analyses rather than large randomized controlled trials specifically designed for BED
Dietary modifications including reducing sulphur-rich foods, eating smaller portions, and avoiding high-fat meals can minimise symptoms