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Production of CoQ-10 in the body declines as we age
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N-terminal acetylation, the Nle 4 substitution (methionine replaced by norleucine, oxidation-resistant), the D-Phe 7 substitution (stereochemical inversion resistant to proteolysis) and lactam cyclization are the four pharmacochemical innovations that transform alpha-MSH's 2-5 minute half-life into a multi-hour half-life
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Research suggests that peptides with the potential of influencing rhythmic endocrine communication may hold relevance beyond isolated hormone investigation alone
