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Fourth, MR requires stringent assumptions, i.e., the genetic variants are associated with the exposure, no confounders of the associations of the genetic variants with the outcomes exist, and the genetic variants are not associated with the outcomes other than via affecting the relevant exposure (no pleiotropy) [17]

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Particularly intriguing is the observation that comparable wave-like ferroptotic activity has also been identified during avian embryonic limb muscle remodeling, where oxidative fronts appear to contribute to the physiological elimination of transient muscle populations