Similarly, in the current trial, oral semaglutide was well-tolerated with no trend towards an increase in the proportion of subjects with AEs with increasing degree of renal impairment, which is in line with the lack of a consistent effect of renal dysfunction on semaglutide exposure
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Of interest, in the study design, the company states that included individuals had a flexible dosing protocol [125], which could have accounted for not meeting the desired 25% body weight reduction target
Indication expansion, such as approvals for additional metabolic and cardiovascular conditions, is broadening patient access and driving adoption
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