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Several Medicare Administrative Contractors (MACs) have local coverage determinations (LCDs), local coverage articles (LCAs), or published bulletins specifying the HCPCS code required for ophthalmic use of bevacizumab, and these can be reviewed at aao.org/lcds

Intravenous therapy is not new

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The BNF recently (2019) changed its guidance for the frequency of injections of hydroxocobalamin: Every 2 months in patients who have neurological symptoms Every 2 or 3 months when there are no neurological symptoms

Its important to know the differences to treat patients well

Any significant deviation from the initial appearancesuch as darkening, fading, cloudiness, or particle formationshould prompt immediate contact with the compounding pharmacy before administration