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2012, Aug;27(9):107577

Supplement alternatives to ALA If youre exploring options beyond alpha-lipoic acid for nerve health or oxidative stress, two of the most studied and promising alternatives are vitamin B12 and acetyl-L-carnitine (ALCAR).56 Each plays a unique role in nerve protection and repair, particularly in the context of diabetic neuropathy

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This research is largely driven by early biomarker discoveries showing that many ME/CFS patients suffer from a deficiency in serum acylcarnitine, which directly impairs mitochondrial oxidative phosphorylation