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Specific research directions include: Glucose homeostasis and -cell function type 2 diabetes models, studies of glucose-dependent insulin secretion, protection of -cells against lipotoxicity and glucotoxicity Central appetite regulation DIO models, mapping of activation areas by c-fos imaging, studies of POMC-MC4R pathways Modulation of the reward system and food preferences behavioural studies in rodents, food-preference models, studies in the mesolimbic circuit Cardioprotection independent of body-weight reduction models of myocardial infarction, atherosclerosis (apoE-/-), heart failure with preserved ejection fraction (HFpEF) Neuroprotection in Parkinsons and Alzheimers models studies of GLP-1R activation in dopaminergic neurons of the substantia nigra and in the hippocampus Modulation of eating disorders and addictions alcohol use disorder and binge-eating models, behavioural studies in the mesolimbic circuit Quality specification Pro-Body Each batch of SEMA G 4 mg PEN undergoes a full cycle of analytical control: HPLC 98% reversed-phase high-performance liquid chromatography with UV detection at 214 nm and 280 nm verification of peptide purity and identification of related impurities MS confirmation Q-TOF mass spectrometry identity confirmation at the level of monoisotopic mass and fragmentation characteristic of the acylated molecule COA per batch a certificate of analysis for every batch available as an inline PDF on the product page

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