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Importantly, the presence of side effects may also serve as a clinical cue that the appetite-regulating mechanism is active , though any severe or persistent symptoms warrant reevaluation of dose or co-therapy timing
Dehydration can worsen vaginal dryness and irritation, and Ozempic-related side effects like nausea, vomiting, or diarrhea can increase fluid loss
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Recently, it has been reported intraperitoneal administration of GLP-1RA activates mesenteric ganglia located periphery to the IML and inhibits intestinal motility 40 ,which is consistent with our results
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