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Preclinical studies report approximately 1.6 increases in intracellular NAD+ following NNMT inhibition in adipocyte models

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In a seminal study in diet-induced obese mice, 5-amino-1MQ administration led to a 35% reduction in mass and size, a 30% decrease in adipocyte size, and a 40% decrease in adipocyte volume in the rodents

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Applications include investigating sarcopenia prevention, athletic performance enhancement, and age-related muscle decline through stem cell pathway activation