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Pratt and members of the Dixon and Olzmann labs for discussion and comments on the manuscript

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Coupled steady-state kinetic measurements with GSSR and GSH revealed that both half-reactions usually occur with second order rate constants around 10 5 to 10 6 M 1 s 1 with the reductive half-reaction being slower for wild-type glutaredoxins 11,14,15,17,19

Interestingly, Chac1 expression is decreased in livers of patients with MASLD, highlighting its potential therapeutic relevance

10.1016/S0092-8674(00)80595-4 19 BrunetA.SweeneyL