Castaigne, Jean-Paul
Initial Loading Phase Protocol In this first step, patients get B12 shots every day for one to two weeks
By inhibiting NNMT using agents such as 5-amino-1MQ, it's possible to enhance NAD+ levels and activate genes that promote metabolism
Benefits Include: Average loss (with healthy diet) 26.6% body weight/84 weeks Lowers Ha1C and improves insulin sensitivity Less nausea than GLP-1 only Can exercise on program and use long term More Weight loss programs Peptide Therapy Peptides are short sequences of amino acids
GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord
While these immediate effects can be encouraging, they are often short-lived unless supported by regular injections and other complementary treatments or lifestyle changes