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In pathological hypertrophy, the heart is associated with cardiomyocyte death, myocardial fibrosis, incomplete reversibility of hypertrophy, and metabolic remodeling of the myocardium, which ultimately leads to systolic dysfunction and HF (99)

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Week 1-2: 0.5mg to 1mg once daily Week 3-4: 1mg once daily Week 5 onward: 1mg to 1.5mg once daily This gradual approach lets researchers assess tolerance

This requirement increases to 2.8 mcg per day during pregnancy and breastfeeding

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This would be especially true where there is insufficient intrinsic factor produced and/or where the ileum of the small of the intestine is no longer present or able to absorb the vitamin B12/intrinsic factor complex