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For instance, the ability of mesenchymal stem cells (MSCs) to undergo osteogenesis is inhibited by loss of NRF2, whereas overexpression increases MSC proliferation (Yuan et al., 2017)

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Melatonin affects transcriptional outcomes and chromatin architecture by promoting histone deacetylation through the upregulation of sirtuin activity, specifically SIRT1 and SIRT3 (Duan et al

Heritability estimates range from 50% to 90%, underscoring the strong genetic contribution to its pathogenesis (Griesi-Oliveira and Serti 2017

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