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However, the participants in the STEP study were severely overweight with an average BMI of 37~38kg/, and the clinical trial was conducted according to overall Western obesity standards
Bettge K, Kahle M, Abd El Aziz MS, Meier JJ, Nauck MA
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The melanocortin 4 receptor (MC4R) may be localized within the central nervous system, perhaps in the hypothalamus
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