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For a brief description, GLP-1RAs attenuate and stabilize the development of atherosclerotic plaques through anti-inflammatory mechanisms and preventing vascular remodeling, and inhibit activation and recruitment of macrophages in atherosclerosis

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the proportion of female participants was 51.1% and 49.2%, respectively

Blood sugar crashescalled hypoglycemiapose the most serious risk, potentially causing confusion, loss of consciousness, or seizures if glucose levels drop below 54 mg/dL

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Importantly, renal and hepatic impairment do not meaningfully alter tirzepatide pharmacokinetics, and no dose adjustments are required for patients with kidney or liver disease