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O'Malley 2011
They can stimulate insulin release when blood sugar is elevated, reduce the release of glucagon, slow the movement of food through the stomach, and influence areas of the brain involved in appetite
However, with modern alternatives entering the scene, its time to reassess whether metformin still deserves its first-line status in 2026
Patients with a history of diabetic retinopathy should be monitored appropriately, and any visual changes should be reported promptly
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