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doi: 10.1016/j.clinthera.2013.11.002 16 MorettoTJMiltonDRRidgeTDMacconellLAOkersonTWolkaAMet al

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The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages

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Pancreatic CAFs (pCAFs) are responsible of ECM deposition, immune evasion/exclusion and support tumor growth contributing to generate the high desmoplastic stroma typical of PDAC [17, 18]

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