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Thus, Western diet shifts the GH/IGF-1 axis to abnormally high levels, just in the opposite direction of low IIS observed in Laron syndrome [1, 2] (Figure 1)

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Other mitochondrial ABC transporters, such as ABCB6, ABCB7, and ABCB10, also contribute to iron metabolism and porphyrin transport, with mutations in these genes associated with various human diseases [134]

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Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jdar E, Leiter LA, et al

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