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Secreted predominantly by the pineal gland, melatonin coordinates circadian rhythms and peaks during the night in healthy individuals
A 2023 meta-analysis found that GLP-1 treatment significantly increased the natural pregnancy rate and improved menstrual regularity in women with PCOS 12
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10.1080/09205063.2022.2088528 79 IkramM.JavedB.HassanS
This interval aligns with recommendations from the Bone Health and Osteoporosis Foundation (BHOF) and allows sufficient time to detect clinically meaningful changes in bone density while enabling timely intervention if significant loss is identified
But both GLP-1-specific studies used laboratory conditions (animal models and cell cultures), not human clinical trials of oral supplementation
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