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Example 3 On the basis of example 1, the condensing agent used in coupling Boc-His (Trt) -Aib-OH was replaced by HATU/DIEA, and the HPLC detection result of the obtained crude semaglutide peptide is shown in FIG

doi: 10.1001/jamanetworkopen.2024.60283 9

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Furthermore, GLP-1RAs have been shown to attenuate microglial activation and improve memory-related behaviors