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HIF-1 is the key transcriptional factor that masterfully regulates endothelial cell biology and angiogenesis, particularly under hypoxic and oxidative stress conditions, by upregulating pro-angiogenic factors, such as VEGF 33
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300 mg/kg per day for 6 days or 900 mg/kg for one day) was found the hepatoprotective effect against APAP-induced hepatotoxicity by reducing the serum concentration of ALT, AST, and lactate dehydrogenase (LDH) in patients (Mroueh et al., 2004)
Since superoxide anion cannot diffuse across the inner mitochondrial membrane it remains in the matrix which allows it to react with Fe-S groups in mitochondrial proteins resulting in the liberation of ferrous (Fe 2+ ) iron
