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A.CoelhoR.et al (2019)

The rate of weight loss mattersmore gradual reduction may cause fewer menstrual disruptions than rapid weight loss, though tirzepatide-induced weight loss occurs relatively quickly compared to lifestyle modification alone

Research is ongoing, but experts generally agree that significant weight loss can contribute to reductions in bone mineral density if muscle and bone are not adequately stimulated through exercise

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For emergency or urgent procedures, surgery typically proceeds with appropriate precautions according to local policy