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After binding of LH-RH, the LH-RH receptor-LH-RH complex is coupled to G 1 protein and activates phosphotyrosine phosphatase, which dephosphorylates receptors for epidermal growth factor (EGF), blocking the signal pathways 3,6

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The previous studies demonstrated that gut extracts possess a hormone that tightly regulates the secretion of pancreas and was named as glucose-lowering element or incretin (INtestine seCRETtion Insulin)

Webpage: Cleveland Clinic [Cleveland, OH]

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